Wednesday, November 7, 2012

UC San Francisco Researchers: "Chernobyl cleanup workers had significantly increased risk of leukemia"


even with the cumulative radiation exposure of less than 100 millisieverts, as Nikkei reports (quoting Kyodo), supposedly from the paper published on November 8, 2012 in the journal Environmental Health Perspective. (I haven't found the paper yet.)

Here's from Eurekaalert.org (11/8/2012; emphasis is mine), UCSF Press Release:

Chernobyl cleanup workers had significantly increased risk of leukemia
Findings may help estimate cancer risk from low-dose exposures like CT scans

A 20-year study following 110,645 workers who helped clean up after the 1986 Chernobyl nuclear power plant accident in the former Soviet territory of Ukraine shows that the workers share a significant increased risk of developing leukemia. The results may help scientists better define cancer risk associated with low doses of radiation from medical diagnostic radiation procedures such as computed tomography scans and other sources.

In the journal Environmental Health Perspectives this week, an international team led by scientists at the University of California, San Francisco (UCSF) and the Chernobyl Research Unit at the Radiation Epidemiology Branch of the National Cancer Institute describes the increased risks of leukemia among these workers between 1986 and 2006. The risk included a greater-than-expected number of cases of chronic lymphocytic leukemia, which many experts did not consider to be associated with radiation exposure in the past.

The new work is the largest and longest study to date involving Chernobyl cleanup workers who worked at or near the nuclear complex in the aftermath of the accident.

Overall, there were 137 cases of leukemia among the workers over the 20-year span of the study, and 16 percent of those cancers were attributable to the Chernobyl radiation exposure, the team found.

The findings shed light on the thorny issue of estimating cancer risk from low doses of radiation – an issue of importance to miners, nuclear workers and anyone who is chronically exposed to low levels of radiation at work or patients who receive sizeable radiation doses when undergoing medical diagnostic tests.

"Low doses of radiation are important," said the lead researcher Lydia Zablotska, MD, PhD, an associate professor of epidemiology and biostatistics at UCSF. "We want to raise awareness of that."

Worst Nuclear Accident of All Time

The nearly 111,000 Ukrainian workers in the study were among the more than 500,000 former Soviets who worked directly on the front lines in the aftermath of Chernobyl disaster, which was the worst nuclear accident of the 20th century followed by the 2011 Fukushima disaster in Japan.

It began in the early morning hours of April 26, 1986 when a planned test of a backup system for operating cooling pumps went awry. A combination of human error and unsafe reactor design led to the runaway production of heat in Chernobyl's Reactor No. 4, which quickly caused two massive explosions, ruptured the reactor, crumbled the building, exposed the nuclear core, rained radioactive debris around the compound and spread fallout through the atmosphere over the Soviet Union and Europe.

Many of the Ukrainian workers were exposed to high levels of radiation because they were part of the teams that helped sweep up contaminated debris from the immediate area – much of which was highly radioactive. Some of them, in fact, reached lifetime limits of radiation exposure within a matter of a few hours.

Although an elevated radiation-related risk of leukemia was not surprising, given the level of exposure among many of these workers, what did surprise Zablotska and her colleagues was the elevated risk of chronic lymphocytic leukemia (CLL), which was similar in size to the risk estimated for non-CLL leukemia.

Leukemia and Low-Dose Radiation

For many years, doctors have known that ionizing radiation from an X-ray source or produced by the decay of radioactive elements can cause leukemia, because it can penetrate the body, expose bone marrow to the radiation and damage DNA. But while scientists have understood this basic mechanism for decades, the question of how much leukemia risk is associated with moderate or low doses of radiation has been hard to answer.

For many years, the best estimates came from long-term studies involving survivors of the 1945 atomic bomb detonations over Hiroshima and Nagasaki, Japan during World War II. People in the immediate vicinity of the blasts were exposed to various levels of radiation, and in the decades afterward, their health was monitored and the increase in cancer tracked.

From those assessments of cancer risk, scientists estimated risks from lower doses by extrapolating the data down. But there have always been problems with this approach, said Zablotska. Atomic bomb survivors were bathed in gamma or neutron rays, while someone who undergoes a CT scan in the U.S. is exposed to X-rays, a different type of radiation. Moreover, extrapolating risks for Japanese population to Western population is further confounded by differences in genetics, lifestyle and diet between the two.

The new work helps to bridge this gap because the doses received by the Ukrainian cleanup workers falls somewhere in between the high level received by the Japanese atomic bomb victims and the lower levels received by people who undergo extensive medical scans.

It also challenges the idea that chronic lymphocytic leukemia is not linked to radiation exposure – something that earlier studies of atomic bomb survivors had seemed to support.

The genetic makeup of the Japanese population may have hidden any increased risk, Zablotska said, because they are much less likely to develop this type of cancer anyway. Chronic lymphocytic leukemia accounts for only 3 percent of all cases of leukemia in Japan – as opposed to about one-third of all leukemia cases in the U.S. and 40 percent of all cases of leukemia in Ukraine.
###

The article, "Radiation and the Risk of Chronic Lymphocytic and Other Leukemias among Chernobyl Cleanup Workers" by Lydia B. Zablotska, Dimitry Bazyka, Jay H. Lubin, Nataliya Gudzenko, Mark P. Little, Maureen Hatch, Stuart Finch, Irina Dyagil, Robert F. Reiss, Vadim V. Chumak, Andre Bouville, Vladimir Drozdovitch, Victor P. Kryuchkov, Ivan Golovanov, Elena Bakhanova, Nataliya Babkina, Tatiana Lubarets, Volodymyr Bebeshko, Anatoly Romanenko and Kiyohiko Mabuchi will be published online by the journal Environmental Health Perspectives on November 8th, 2012. See: http://ehp03.niehs.nih.gov/

In addition to UCSF, authors on this study are associated with the National Research Center for Radiation Medicine in Kyiv, Ukraine; the National Cancer Institute in Bethesda, Md.; Robert Wood Johnson Medical School in Camden, N.J.; Columbia University in New York City; and Burnasyan Federal Medical Biophysical Centre in Moscow.

This study was funded by the National Cancer Institute (NCI) through grant #CA132918 and contract #NO1-CP-21178 and by the Intra-Agency Agreement between the NCI and the National Institute of Allergy and Infectious Diseases (NIAID) through agreement #Y2-Al-5077 and #Y3-CO-5117. Both NCI and NIAID are part of the National Institutes of Health (NIH).

Additional support was provided by the U.S. Department of Energy (contract HHSN 261 2004 55796C), the Nuclear Regulatory Commission, and the French Institute for Radiological Protection and Nuclear Safety.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco


The Japanese "safety" limit for workers doing decontamination, aka "shifting contamination elsewhere", is maximum 50 millisieverts per year, and maximum 100 millisieverts total in 5 years - same as radiation workers at nuclear power plants.

But as then-Minister of the Environment Goshi Hosono said, "Japan is different! We're not Russia! We have advanced decontamination technology!" Like screwdrivers.

The country is different indeed, that's for sure.

1 comments:

Anonymous said...

Pneumonia as a first weak signal (reduction of the immune system, due to low and continuous radiation), leukemia and many others in the years to come :-(
http://idsc.nih.go.jp/idwr/kanja/weeklygraph/18myco-e.html

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