Showing posts with label STAP cell. Show all posts
Showing posts with label STAP cell. Show all posts

Wednesday, December 31, 2014

Tying Loose Ends at 2014 End: #Fukushima I NPP R4 SFP Emptied, STAP Was Outright Fraud, Potential Radioactive Leak in Ukraine


All fuel assemblies - 1331 used and 202 new - in the Spent Fuel Pool of Reactor 4 at Fukushima I Nuclear Power Plant have been moved out of the pool. Most have gone to the Common Pool on the ground level. Some have been moved to the Spent Fuel Pool of Reactor 6, as they ran out of space in the Common Pool.

I suppose the purpose of the whole exercise was to placate those who were screaming "End of the world is near!" because "Reactor 4's building would collapse at any moment!" in various parts of the world (particularly North America). Condolences to workers who had to do the actual work and were exposed to large doses of gamma radiation that came from the operating floor of Reactor 3 right next, and from the Reactor 4 spent fuel pool itself due to the high level of cobalt-60 in the water in the Spent Fuel Pool; the water came from the DSP (device storage pool, where Reactor 4's core shroud had been stored temporarily) when the gate to the SFP was damaged in probably one of the aftershocks after the March 11, 2011 big earthquake and let the DSP water flood into the SFP. I wonder if TEPCO ever decontaminated the pool water.


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Riken finally and very bluntly announced that the experiment to "recreate" STAP cells was a failure. Not even the 31-year-old Dr. (for now, till Waseda University, aka "PhD diploma mills" as many say now, revokes her degree) Haruko Obokata, who claims to have created the so-called STAP cells more than 200 times, couldn't do it, not even once. DNA analysis proved that Obokata's novel "STAP" cells were nothing but ES (embryonic stem) cells already known and widely used by reseachers.

Riken also concluded that there was NO EVIDENCE that Obokata had actually done the experiments that were reported in the Nature paper and letter. Everything, most likely, was made up. Outright fraud. I wonder if Harvard University is doing any investigation. After all, the Vacanti (of Vacanti-mouse fame) lab is where Obokata learned the trick.

Dr. Obokata released the statement saying she had "tried beyond my soul," whatever that means. Some accuse her of plagiarizing a famous sumo wrestler's words when he announced his retirement. (It seems to me that Obokata had confessed to her fraud when she said back in June this year that she wanted to be reunited with her "sons". Estranged Sons. ES.)

However, Riken very generously exonerated Obokata by saying they couldn't identify who "mixed in" ES cells more than 200 times.

From Riken's English summary of the detailed report (which is only available in Japanese, for experts and researchers):

It is unlikely that there was accidental contamination by three different ES cells, and it is suspected that the contamination may have occurred artificially. However, given the difficulty of identifying who might have contaminated the cultures, it is not possible to conclusively determine that it was artificial contamination. We cannot, therefore, conclude that there was research misconduct in this instance.


Obokata was allowed to quietly resign. It's good to be very well connected, I suppose, having Prime Minister and Minister of Education as fans.

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The US and the West propaganda of Russia being the cause of all ills in the world notwithstanding, this one doesn't seem like being caused by Russia. There is a media report that the largest nuclear power plant in Ukraine and in Europe (and 5th largest in the world) may have a radioactive leak. The source of this news is RT, which has unfortunately not been that reliable when it comes to news about the Fukushima nuclear accident. RT quotes LifeNews that reports leaked official report.

From RT (12/31/2014):

A radioactive leak has been detected at Ukraine’s Zaporozhye Nuclear Power Plant, the largest in Europe, a media report says, citing the country’s emergency services. Ukrainian officials have denied the report.

LifeNews published what it claims is a leaked report by the State Emergency Service of Ukraine, which denies an earlier assessment by the plant’s authorities that the radiation at the facility is equal to the natural background following an incident on Sunday.

RT is trying to verify the report.

Ukrainian authorities have denied the Russian media report that a radioactive leak had taken place at the plant, Reuters reported.

"The plant works normally, there have been no accidents," an energy ministry official told the news agency. No official comment on whether the leaked documents are authentic has been provided.

Two documents released by LifeNews appear to show that the plant's officials put deliberately misleading information on their website. The documents – both addressed to the head of the regional emergency services – state that radiation levels at the plant on Sunday and Monday were 16.8 times higher than the legally permitted norm.

By Monday, the levels had slightly increased – growing from 16.3 to 16.8 times higher, and Unit 6 was still shut down, the report said, contradicting the plant's statements that the problem had been fixed and that the plant was operating normally.

(Full text at the link)


The article also says that the US Westinghouse (Toshiba) will "significantly increase fuel deliveries to Ukrainian nuclear power plants through 2020".

Good luck Ukrainians, if what Russia's Sputnik news agency has been tweeting is true.

From Sputnik (12/30/2014):

Nuclear energy experts and officials have repeatedly warned the Ukrainian authorities that it would be unsafe to use US-made fuel in reactors of Soviet and Russian design.


Happy New Year, everyone. I hope we will somehow survive and thrive in 2015, the year of sheep. (...)

Wednesday, June 11, 2014

(OT) STAP Cell Researcher Says, "I Want to Be Reunited with My Sons from Whom I've Been Separated"


So, the so-called "STAP cells" have undergone gender reassignment - from "princess" cells as Ms. Obokata (lead author of the two Nature papers) once wanted to name them, to "my sons".

There's got to be a better profession for this so-called researcher than being a researcher. A comedienne or a politician comes to mind.

According to Mainichi Shinbun (6/11/2014), Ms. Obokata, who has been staying at a hospital, has been in fact "advising" Riken researchers how to create the so-called STAP cells since last month.

Mainichi also quotes the lead attorney employed by Ms. Obokata (she has four attorneys), who told the press that his client says she wants to look for her sons (STAP cells) whom she has been separated from.

One prominent Japanese scientist (and a mother) who heads a laboratory in a US research institution is furious, and she tweeted, "You have already made a mockery of biology. Stop insulting women and female researchers further. I'm ashamed."

Other net citizens wonder aloud how Ms. Obokata could look for her "sons" when the "sons" may not have been born to begin with.

Nikkei Science and NHK reported today (6/11/2014) that her "sons" may not be STAP cells but ES cells (embryonic stem cells) with a particular genetic defect. That particular defect, "trisomy" (having three copies) of chromosome 8, has been found in almost all cells that were presented as STAP cells which was supposedly made from one-week-old mice.

Trisomy of chromosome 8 results in death of an embryo. In other words, there cannot be any mouse born with trisomy of chromosome 8, and STAP cells cannot be made from cells taken from a mouse with trisomy of chromosome 8.

On the other hand, 20 to 30 percent of cultured ES cells are known to have trisomy of chromosome 8, according to Nikkei Science and NHK who quote both Riken researchers and Tokyo University researchers who analyzed DNA of the STAP cells.

Oh well, minor details for non-scientists or people with little to no interest in science who are the majority of people in Japan and probably elsewhere. Post-Fukushima Japan (and perhaps elsewhere) seems to think that if you cannot 100% prove certain things do not exist - be they STAP cells or acute effect of long-term low-dose radiation exposure - then it is possible, or even highly probable that these things do exist.

Tuesday, June 3, 2014

(UPDATED: OT) Nature Magazine Says There Were No STAP Stem Cells, Which May Be Just a Mixture of Two Different Types of Stem Cells According to Latest Analysis


(UPDATE 3) The story gets richer by the day. Now it's been found that Professor Charles Vacanti, head of Anesthesiology at Brigham and Women's Hospital and the corresponding author of the Nature paper which he finally agreed to retract after just about everything in the paper was found to be more fantasy than reality, has been awarded US$700,000 grant from the Department of Defense via AxoGen, Inc., "the emerging leader of the $1.6 billion U.S. peripheral nerve repair market" according to the PR on June 4, 2014.

“I am excited about the potential to address challenging nerve repair cases through the use of regenerative medicine and stem cell therapies,” said Vacanti


The US taxpayers are thrilled to fund his research, I suppose.

(UPDATE 2) Yomiuri and other papers reported on 6/5/2014 that Ms. Obokata's job application paper for Riken's position ("unit leader" with close to 100,000 dollars salary) was found to contain more copying and pasting - from her doctoral thesis which is itself full of copying and pasting and from patent applications submitted by Harvard University. It would be a surprise if there is anything, anything at all that this so-called researcher has ever produced without copying and pasting someone else's work.

(UPDATE) So it was a pressure exerted by Nature Magazine on Charles Vacanti. According to Asahi Shinbun (6/5/2014), Nature strongly suggested Vacanti agree to withdraw the papers (only Vacanti and Obokata were holding out) instead of Nature doing it without his consent. After Vacanti folded, Obokata folded.

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Fraud through and through, it seems to me.

The latest developments came on June 3, 2014, when NHK reported on two different investigations done on these so-called STAP (stimulus-triggered acquisition of pluripotency) cells (which was originally to be called "princess cells" - princess woken up by a kiss from a prince, no less - by the lead author of the two papers accepted by Nature).

According to NHK News (6/3/2014):

- Genetic analysis of the cells created from STAP cells shows these cells were from the mice different from those supposedly used in the experiment detailed in the Nature papers.

- The cells were supposed to be created from "F1" mouse according to the Nature papers, but in fact they were from "B6" and "CD1" mouse.

- Cells from "B6" mouse are similar to "ES cells (embryonic stem cells)", and cells from "CD1" mouse are similar to "TS cells (trophoblast stem cells).

Ms. Obokata's secret recipe may have been to mix ES cells and TS cells cleverly. There was no STAP stem cell, there is no STAP stem cell, as even the magazine that published the two papers now admits.

And what is Riken going to do? Nothing. They have said they will continue their effort to recreate the experiment that supposedly created so-called STAP cells. Their best luck would be to mix ES cells and TS cells, just like the lead author (and probably the corresponding author Charles Vacanti) probably did. The top management of Riken seems eager to protect their star scientist Sasai, who was the mentor to Ms. Obokata and the promoter of her and her STAP cells, and shut down the investigation before it ensnares him.

Then today (6/4/21014), Nikkei Shinbun reports that Ms. Obokata has finally agree to retract the Nature paper, as well as the letter. NHK says the corresponding author Professor Charles Vacanti may now be willing to retract the paper.

About time to put this sorry saga to rest, but many net citizens (mostly males) in Japan continue to firmly believe it is some kind of a huge conspiracy by male-dominated research institutions and the national government to monopolize these so-called STAP cells. Poor little girl, they say.

The lead attorney assisting Ms. Obokata in dealing with Riken says she is still hospitalized and too weak (from unspecified illness, like some celebrities or politicians) and says she has probably been pressured by Riken to accept the retraction.

So far, there is no investigation by Harvard University and Nature Magazine. Waseda University, which conferred Obokata her doctoral degree, apparently does not understand what's wrong with copying and pasting without citations in writing a doctoral thesis.

Tuesday, April 8, 2014

(OT) "STAP Cell Is Truth, I Have Encountered It Many Times!" 30-Year Old Riken Researcher Pleads in Press Conference


Whatever.

Having already hired not just one or not even three but FOUR attorneys in preparation to fight her employer Riken, the prestigious research institution in Japan who has in fact re-hired her with taxpayers' money ($150,000 a year, I hear) as of April Fools' Day, Ms. Haruko Obokata is holding a press conference in Osaka with more than 200 reporters attending.

The 30-year-old PhD (for now, until Waseda University strips her of the doctoral degree) is fully employing the girl-like charm with blank stares, shifting eyes as if she is about to cry for an effect, well-coiffed old-fashioned hair style, and is speaking like an elementary school girl who is trying hard to make excuse for her bad behavior or missing homework. "Poor me! Look at me I'm suffering!"


"STAP cell phenomenon is truth, I have encountered it many times. Just because my paper was not well-prepared, why should STAP cell be denied?"

Well, a total fiction can be truth, as a female novelist from nearly 1000 years ago in Japan wrote in her phenomenal Tale of Genji.

Your paper, which you wrote with the vice president of Riken and your Harvard University professor (Mr. Charles Vacanti, an anesthesiologist), is full of borrowed and photoshopped photographs and borrowed texts without attribution. The key photograph that was supposed to prove the existence of your STAP cell was copied and photoshopped by you from your own doctoral thesis at Waseda University.

I couldn't stand to watch the press conference (live on USTREAM right now) any longer. It has devolved into tabloid news.

"There is no photograph that shows what does not exist, therefore it is not a fabrication," Obokata just said.

She is no scientist, and the Japanese media is no scientist. They deserve each other.

As to the STAP cell itself, after many attempts to reproduce the result, Professor Ken Lee of Chinese University of Hong Kong has thrown in the towel after all, and has gone back to his own research. He said in his ResearchGate post 5 days ago:

"I don’t think STAP cells exist and it will be a waste of manpower and research funding to carry on with this experiment any further. "


Meanwhile I haven't heard any news about Nature Magazine investigating its "peer-review" system, or about Harvard University investigating Professor Vacanti's lab.

Tuesday, April 1, 2014

Happy April Fools' Day! Residents Back in 20km Evacuation Zone in #Fukushima, TEPCO Manages to Contaminate Brand-New Tanks, 30-Year-Old STAP Cell Researcher Says She Meant Well When She Copied and Pasted for Nature Magazine Thesis


April 1st is the start of Japan's new fiscal year. Fitting, you might say.

Residents who were forced to leave their homes in Miyakoji District of Tamura City soon after the start of the nuclear accident on March 11, 2011 are allowed back, as of April 1st, 2014. They are the first in the former no-entry evacuation zone within 20-kilometer radius from Fukushima I Nuclear Power Plant.

NBC News in the US has a Reuters article whose only sensationalism is in the title (Miyakoji was never "hot"); otherwise the article simply reports facts, and surprisingly, with numbers for radiation levels, which rarely happens in the articles in the US mainstream media on the Fukushima accident, or any nuclear accident.

It is still a joke. Not because the Japanese government is sending the residents back in the "hot zone" (as Reuters' article says, which is misleading) in 3 "short" years, but because the residents in Miyakoji should never have been forced to leave to begin with.

The radiation levels in Miyakoji, even though the town is inside the 20-kilometer radius, have generally been much lower than larger cities in the more populous middle-third of Fukushima Prefecture ("Nakadori"), where residents have never been forced to evacuate. It's all because of the unscientific, uninformed decision by the ministers of the Kan administration (PM Naoto Kan, Cabinet Secretary Yukio Edano, Minister of Economy Banri Kaieda) to draw concentric circles around the plant to decide the evacuation zone - as if the nuclear plant accident were an atomic bomb detonation, and as if that had happened on a flat land on a day with no wind.

From NBC News quoting Reuters (4/1/2014; emphasis is mine):

Fukushima Families Return to Homes in 'Hot Zone'

The completion of decontamination work allowed residents of a small part of the Fukushima exclusion zone to return home Tuesday, just over three years after they were forced into exile.

The reopening of the Miyakoji area of Tamura, a city inland from the wrecked nuclear station, marks a tiny step for Japan as it attempts to recover from the 2011 disasters.

But the event is a major milestone for the 357 registered residents of the district. The trickle of returnees highlights both people's desire to return to the forested hamlet and the difficulty of returning to normal.

"Many of our friends and neighbors won't come back," said Kimiko Koyama, 69, speaking on her return to the large farmhouse she had occupied for 50 years, while her husband Toshio, 72, tried to fix a television antenna on the roof.

"There are no jobs. It's inconvenient and young people are scared of radiation," she said. "My daughter won't bring our grandsons here because of the radiation."

A few cars streamed into the town on Tuesday, where several TV news vans were set up. Some elderly women sat by the roadside, but there were no children or families in sight outside.

Schools open later this week, but seven children came to the local pre-school and four older children were also dropped off, as volunteers from nuclear plant operator Tokyo Electric Power (Tepco) removed ice and snow and leveled the playground.

Radiation levels in Miyakoji ranged from 0.11 microsieverts to 0.48 microsieverts per hour, February readings show.

That was higher than the average 0.034 microsieverts per hour measured in central Tokyo on Monday, but comparable to background radiation of about 0.2 microsieverts per hour in Denver. A commercial flight between Tokyo and New York exposes passengers to about 10 microsieverts per hour.

People exposed to radiation typically have a higher chance of getting cancer if doses exceed 100 millisieverts (100,000 microsieverts), the World Health Organisation says.

Tuesday's homecoming is particularly difficult, as many residents worked at the Fukushima plant before the disaster and depended on Tepco for stable jobs.

"It was the only job out here and we were grateful," said Kimiko Koyama. "We worked hard to feed our three daughters. We worked and we built our life here."

The Koyamas, who helped to build the very nuclear reactors that have displaced them from their homes, are letting the city keep radioactive debris in an empty lot on their land in a bid to hasten the cleanup.


The Koyamas at their home, photo by Reuters:


In Japan, you don't actually hear much about fear of radiation as reason for not returning for these residents. Rather, the concern is not radiation (whose levels are lower than in cities like Fukushima and Koriyama in the middle third), but local economy.

As Reuters' article above briefly mentions, the employment in the district depended heavily on TEPCO. But it is not just employment. Residents used to go to neighboring Okuma-machi and Futaba-machi, both of which are inside the 20-kilometer radius evacuation zone and actually heavily contaminated, for shopping, seeing doctors, entertainment, etc. Both Okuma-machi and Futaba-machi are off-limits for years to come.

According to the latest measurement by Tamura City, Miyakoji District's radiation level as of March 30, 2014 was 0.14 microgray/hour (more or less the same as 0.14 microsievert/hour).

According to the real-time monitoring information compiled at Nuclear Regulation Authority, radiation levels in Koriyama City in the middle-third of Fukushima Prefecture range from 0.09 microsievert/hour to 0.595 microsievert/hour (which happens to be in a nursery school...). The levels in Miyakoji District in Tamura City look to be between 0.1 and 0.2 microsievert/hour.

One clarification about the radiation dose of 100 millisieverts mentioned in the article: it is about life-time cumulative dose.

Now, moving on to TEPCO, you will encounter a joke in the true sense of the word...

The stoppage of all three lines of ALPS was my last post in March, but since then the multi-nuclide removal system has been plagued with new leaks and other problems that cause constant stoppage.

The saddest and stupidest of all must be this (or at least it is for me): TEPCO unknowingly contaminated the brand-new 1,000-tonne welded tanks as they kept sending the water treated by ALPS, except ALPS wasn't treating the waste water properly (for reasons not yet clear) and left a significant amount of beta nuclides in the water.

TEPCO (or rather, Toshiba) didn't have a way to test the water treated by the three ALPS lines individually. Treated water from the three lines all goes to the same holding tank, from which the water is sent to the storage tanks.

There are 21 such brand-new, welded tanks, and TEPCO has admitted that 9 of them have been contaminated (10 million Bq/Liter of all beta). I have a suspicion that all 21 tanks have been contaminated. Why? Because these tanks are all connected by pipes and valves near the bottom of the tanks, and they keep the valves open to fill all tanks by pumping the treated water into one tank

Now, someone has to crawl inside the tanks from the inspection holes near the bottom, and scrub the inside clean.

From Tokyo Shinbun (3/26/2014; part):

東京電力福島第一原発の新型除染装置「ALPS(アルプス)」で不具合が起きているのに東電が運転を続けた結果、多数のタンクを高濃度の放射性物質で汚した。東電は「タンクの除染を始めた」というが、後始末をさせられるのは作業員。除染に当たった作業員らが語る現場は、過酷だった

TEPCO continued to operate ALPS, the multi-nuclide removal system at Fukushima I Nuclear Power Plant, without noticing the problem. As the result, many tanks were contaminated by highly radioactive materials. TEPCO says it has started to "decontaminate the tanks", but the ones who do the actual decontamination are the workers. As told by the workers who did the decontamination, it was a hard labor.

除染されたのは、ALPSで処理した水を一時的にためるため、装置脇にあるタンク一基。作業員らはタンク下部の側面に直径八十センチほどの点検孔を開け、高さ、直径ともに約十メートルあるタンクの中に入った。天板に二カ所ある点検孔を開け、そこから差し込むわずかな光と持ち込んだ発光ダイオード(LED)ライトの光だけが頼りだ。

Workers decontaminated one tank near ALPS which temporarily stores water treated by ALPS. They opened an inspection hole, 80 centimeters in diameter, at the side of the tank near the bottom to enter the tank with 10 meters in diameter and in height. They opened the two inspection hole on the ceiling to let the light. They also carried in the LED lights for the work.

すでに上部から高圧の水を吹きつけて洗浄してあるとはいえ、つい数日前まで一リットル当たり一〇〇〇万ベクレルと、放出基準の数十万倍もある放射性ストロンチウムなどを含む水が入っていた。ベータ線を発する物質で、被ばくの心配は少ないが、直接触れたり体内に取り込むと内部被ばくにつながる。

Even though the tank had been washed from above with high-pressure washer, until a few days ago it had stored water that contained 10 million becquerels per liter of radioactive materials including radioactive strontium, hundreds of thousands times the limit for discharge. They were beta nuclides so there was less worry for radiation exposure unless they came into direct contact or they were ingested.

防護服の上にかっぱを二枚重ねし、かっぱのフードを全面マスクの上からテープで密封。手はゴム手袋など四枚重ね。足元は長靴と完全防備だ。

Workers wore two [water-proof] jackets on top of the protective clothing [Tyvek, probably]. The hoods of the jackets were taped shut onto the full-face masks. They wore four layers of gloves including rubber gloves, and wore long boots.



Meanwhile, I hear that TEPCO's president, Mr. Hirose, was welling up as he welcomed new employees (new graduates) for the first time in three years. TEPCO on the road to recovery...

Now, moving on to surreal...

The 30-year old (so-called) researcher at RIKEN, one of the premier research institutions in Japan, who seems to have copied and pasted all the way to her current cushy position, claims her STAP cells are real, and copying and pasting she did to falsify the data was done with good intension - or at least with lack of bad intension.

So in her privileged mind, as long as she doesn't mean ill, she should be forgiven.

For those who are not familiar, she and her professor during her Harvard days, Professor Charles Vacanti, claim they have created a cell that can become any cell from an adult cell just by stressing it a little bit with acid bath or mechanical stress. One of the photographs critical to their claim and prominently featured and published in the prominent peer-reviewed magazine Nature turns out to be the same photograph from her doctoral dissertation from a totally different process.


RIKEN's top management (who happen to be top scientists, too, including a Nobel prize winner in chemistry) held a press conference on April 1st to announce their final findings: The researcher, Ms. Haruko Obokata, knowingly falsified.

Ms. Obokata, now being advised by not just one but THREE lawyers, has this to say (From none other than Nature Magazine, 4/1/2014):

In her letter, Obokata says the spliced gel lane did nothing to change the study’s results. “There was no merit in falsifying data, and I had no intention of doing so when I made the image. I only wanted to have a better image,” she writes. Use of the duplicated image was also “a simple mistake” made because the images were similar. Obokata says that she had already identified the mistakes and sent Nature a correction.


Except she didn't identify the mistakes. Net citizens did. Her "simple mistake" involved photoshopping the original image and editing the text beneath the photos. Such an innocent mistake, she actually claims. As long as the intention is good, she should be forgiven, she says.

RIKEN says it was presented with only two lab notes in the three years Ms. Obokata was with RIKEN, and the commissioners at the press conference said they were effectively just one note, and so poorly written, without dates, that they couldn't verify the data or the origin of the photos.

Ms. Obokata is doubling down, and says she will file a formal complaint with RIKEN, and probably sue them.

For what? No one knows. She probably liked the attention she got in her 15 minutes of fame. RIKEN is under heavy criticism for hiring this person who seems like a pathological liar if you read tabloid magazines and for allowing this to happen. She reportedly won the essay contest when she was in middle school by copying and pasting quotes from a very popular animation (Galaxy Express Three-Nine) and passing them as her own words.

So far, no one has accused Nature Magazine for its sloppy peer review.

Hope you had a fun April Fools' Day...

Wednesday, March 12, 2014

(OT) "Copy & Paste" Your Way to a PhD, to Peer-Reviewed Nature Magazine


This news, at least on the net in Japan, was probably the most talked-about news on March 11, overshadowing the 3rd anniversary of the triple disaster of earthquake, tsunami and nuclear accident.

From Nature's Newsblog (3/10/2014; emphasis is mine):

Call for acid-bath stem-cell paper to be retracted

Less than 40 days after a team led by Haruko Obokata of the RIKEN Center for Developmental Biology in Kobe, Japan, presented two stunning papers claiming a method of using a simple acid-bath method to reprogramme mature mammalian cells back to an embryonic state – so called STAP cells – researchers in Japan, including one of the paper’s co-authors, are calling for them to be retracted.

Within weeks of their January 30 publication, the paper was criticized for irregularities and apparent duplicated images. Numerous scientists also had difficulty reproducing the supposedly simple method. The team responded with the promise of corrections and a list of tips to help other scientists to reproduce the results.

Over the weekend, however, two more serious problems surfaced. The Nature paper was found to contain two images apparently duplicated from Obokata’s doctoral dissertation. Her thesis also reported experiments dealing with cells that were supposedly in an embryonic state, but the cells reported in the Nature paper were said to be derived from a different process in an altogether different experiment.

The revelation has led to a flurry of calls – including some from senior scientists in Japan – for the paper to be retracted.

Perhaps the most damning comes from Teruhiko Wakayama, a cloning expert at Yamanashi University and a corresponding author on one of the papers. Interviewed by NHK news, Wakayama said: “I have lost faith in the paper. Overall there are now just too many uncertainties about it. I think we have to wait for some confirmation.” Wakayama calls for an investigation of all the laboratory notebooks and data. He continues: “To check the legitimacy of the paper, we should retract it, prepare proper data and images, and then use those to demonstrate, with confidence, that the paper is correct.” Wakayama reportedly contacted all of the authors requesting that they agree to retract the paper. RIKEN says it is still investigating the case.


The STAP paper by Obokata also contains "copy and paste" from a paper published in 2005, without any citation or reference.

Professor Charles Vacanti at Harvard Medical School, co-author of the paper on STAP cell, says there is no need for retraction. Professor Vacanti also happens to be one of the researchers who reviewed Ms. Obokata's doctoral thesis in 2011 from Waseda University.

In Japan, this doctoral thesis is now being dissected in details. A huge chunk of the 100-page thesis - 22 pages out of 24-page introduction was found to have been taken from the National Institute of Health website. One of the key photographs was found to have been taken from a commercial biotech company's website. Even the references to several chapters of the thesis turned out to be "copy & paste" from other papers. There is now a doubt whether Ms. Obokata did the experiment as she claimed in the thesis at all.

So far, there is no direct evidence to indicate that STAP cell is also made up, a hoax. However, Nikkan Gendai, a Japanese daily tabloid, raises an interesting point that Obokata and her group used old, dated equipment (which was used in the late 1990s) to take the photographs of STAP cells when her employer, RIKEN, no doubt had the most advanced, top-of-the-line equipment for such purpose.

The Japanese media and politicians have been very eager to present a young, female Japanese scientist to the world. Maybe they have been too eager.