Thursday, December 26, 2013

15-Nation Study on Low Dose Radiation Cancer Risks for Nuclear Workers May Have Been Skewed by Canadian Data

Particularly after the Fukushima nuclear accident, one of the often cited pieces of evidence that even the low dose radiation exposure (less than 100 millisieverts) can increase the risk of (solid) cancer is the study published in 2005 of more than 400,000 nuclear workers in 15 countries.

In looking for the study, I found instead an editorial in British Journal of Cancer (11/14/2013) that suggests the seminal 2005 study of nuclear workers may have been flawed due to the Canadian data that significantly skewed the result because of 3,088 Atomic Energy of Canada Limited workers who were employed between 1956 and 1964 and whose dose information may be incomplete.

For what it's worth. (Emphasis is mine.)

Nuclear worker studies: promise and pitfalls

R Wakeford1

1Centre for Occupational and Environmental Health, Institute of Population Health, The University of Manchester, Ellen Wilkinson Building, Oxford Road, Manchester M13 9PL, UK

Correspondence: Professor R Wakeford, E-mail:

The publication in this issue of BJC of the findings of an updated study of Canadian nuclear industry workers by Zablotska et al (2013) invites enquiry into the background of this and similar studies. Nearly 40 years ago, the Royal Commission on Environmental Pollution (1976) opined that it would be desirable to conduct epidemiological studies of nuclear workers to directly assess risks to health from protracted occupational exposure to ionising radiation, to test the appropriateness of the assumptions made in setting radiation protection standards based largely on the experience of the acutely exposed Japanese survivors of the atomic bombings of Hiroshima and Nagasaki. The next year, the study by Mancuso et al (1977) on nuclear workers at Hanford, WA, appeared to show that cancer risks among these workers were greater than expected; the methodology of this study was heavily criticised (Hutchison et al, 1979), but it received much publicity.

In the United Kingdom, the National Registry for Radiation Workers (NRRW) was established in 1976 (Kendall et al, 1992), and nuclear worker studies were initiated in other countries, notably the United States of America (Gilbert et al, 1989) and Canada (Gribbin et al, 1993). However, it was recognised that international collaboration was highly desirable to increase the statistical power of the worker studies, and in 1988 the International Agency for Research on Cancer (IARC) agreed to coordinate such a collaboration, the first fruits of which appeared in 1995 and involved three countries and seven groups of workers, three from the United States of America (including Hanford), three from the United Kingdom (including Sellafield) and one from Canada (the workers of Atomic Energy of Canada Limited, AECL) (Cardis et al, 1995). The combined data showed a positive association between the risk of mortality from leukaemia (excluding chronic lymphocytic leukaemia, CLL) and the cumulative recorded dose of radiation from external sources, which was of marginal statistical significance, and a (non-significantly) negative association for the risk of all other cancers combined, results that were compatible with conventional risk estimates (Cardis et al, 1995). For AECL workers, the estimates of the excess relative risk (ERR) per sievert were as follows: leukaemia excluding CLL (5 deaths), 48.40 (95% confidence interval (CI): 2.8, >100); all other cancers (324 deaths), 0.13 (95% CI: <0, 2.1) (Cardis et al, 1995).

The IARC-coordinated collaborative study was later extended to 15 countries, and the first report from this study was published in 2005 (Cardis et al, 2005). Although the trend of risk with cumulative external dose was positive for mortality from leukaemia excluding CLL, somewhat surprisingly given the findings of the three-country study it was not statistically significant; but the association with dose for all other cancers was both positive and significant – the ERR/Sv was 0.97 (95% CI: 0.14, 1.97). Moreover, the risk estimate for the group of all other cancers was only just compatible with the prediction of standard risk models, leading to controversial suggestions that the risk of cancer resulting from protracted exposure to radiation in the workplace has been underestimated.

The interpretation of the 15-country study was not, however, straightforward, and one aspect of the findings that troubled both me (Wakeford, 2005, 2009a) and others (United Nations Scientific Committee on the Effects of Atomic Radiation, 2008; Boice, 2010) was the surprisingly large influence of the Canadian workers on the risk estimate for all other cancers – although the Canadian workers contributed around 4% of the deaths, the exclusion of these workers caused a ~40% reduction in the risk estimate (Wakeford, 2005). In fact, the ERR/Sv for the Canadian workers, 6.65 (90% CI: 2.56, 13.0), was notably and significantly larger than the ERR/Sv estimate for the combined workers from the other 14 countries, 0.58 (90% CI: −0.10, 1.39) (Cardis et al, 2007). Of course, this does not mean that the Canadian data are necessarily wrong, but scrutiny of previous findings of studies of Canadian workers, including the three-country study (Cardis et al, 1995), reveals an apparent upward step-change in risk estimates for the group of all other cancers that coincides with the start of the use of Canadian National Dose Registry (NDR) data in the analyses (Wakeford, 2009a).

Ashmore et al (2010) examined the NDR data for the AECL workers, the group of workers who seemed to be the primary reason for the upward change in the Canadian risk estimates. They identified a number of possible deficiencies in the AECL worker data used in the 15-country study, in particular those relating to the data before 1971. They called for a thorough examination of the Canadian worker data, and if appropriate, a new analysis of Canadian worker risks based on revised NDR data.

The Canadian worker data contributing to the 15-country study were those used in the study of Zablotska et al (2004) of workers from AECL and three Canadian electricity-generating companies. Now, Zablotska et al (2013) report the findings of an updated study of 45656 Canadian nuclear industry workers, following a detailed check of dosimetry and employment records, which resulted in a number of changes in the AECL data in the NDR. These revisions led to a reduction in the ERR/Sv for mortality from all solid cancers from 2.80 (95% CI: −0.04, 7.13) to 1.77 (95% CI: −0.42, 5.30), the latter risk estimate being driven by the AECL workers, 3.25 (95% CI: 0.11, 8.85). However, also revealed was a notable difference in the solid cancers ERR/Sv for 3088 (19%) of the AECL workers first employed during 1956–1964, 7.87 (95% CI: 1.88, 19.5), and those first employed after 1964, −1.03 (95% CI: <−1.66, 5.76). Zablotska et al (2013) conclude that the finding for the early AECL workers is likely to be due to remaining data inaccuracies, probably missing dose information, rather than a real effect of radiation exposure, and they believe that use of the pre-1965 AECL worker data cannot be justified until further investigation is undertaken.

So, it would appear that the most reliable results from the 15-country study are for the combined 14 countries excluding Canada, which are not exceptional (see above). For Canada, Zablotska et al (2013) propose that until the findings of further investigations of the AECL data are available, the ERR/Sv estimates should be taken to be those using the post-1964 AECL worker data combined with the data for the workers of the three generating companies: leukaemia excluding CLL (12 deaths), 14.4 (95% CI: <−1.49, 146), and all other cancers (347 deaths), −1.36 (95% CI: <−1.47, 1.98).

Zablotska et al (2013) have indicated that it is intended to further investigate the data for pre-1965 AECL workers with the intention of eventually including them in future studies. Hopefully, this investigation will prove fruitful as the earlier studies of all AECL workers based on an AECL dosimetry database rather than the NDR suggested that these early workers could contribute valuable data – for example, it was pointed out above that a statistically significant positive trend with dose for mortality from leukaemia excluding CLL, was previously reported for all AECL workers (Cardis et al, 1995). It is generally the case that early nuclear workers will have accumulated larger radiation doses than later workers, not only because they have worked longer, but also and importantly because doses received in the early years of the industry were greater (sometimes much greater) than those received in recent years. Consequently, the inclusion of such early workers will considerably improve statistical power, and this is especially the case for workforces in countries with nuclear programmes starting in the 1940s and 1950s, such as Canada. By way of illustration, the recently published third analysis of the NRRW included greater than 10000 workers with cumulative external radiation doses exceeding 100mSv (i.e., moderate doses), but at the time of the analysis only about one-quarter of these workers had died (Muirhead et al, 2009), suggesting that substantial information is still to come.

Studies on radiation workers have the potential to provide valuable evidence on the risks from protracted exposure to low-level radiation. International collaboration remains the obvious way of extracting as much information out of the available data as possible, and these collaborations should certainly continue (Wakeford, 2009b), but the difficulties in conducting such studies and interpreting the results should not be underestimated. The latest Canadian worker study by Zablotska et al (2013) illustrates the care that must be exercised in collating worker data, and the problems that can arise, especially when using data that may have been collected for purposes other than epidemiology.


  1. Ashmore JP, Gentner NE, Osborne RV (2010) Incomplete data on the Canadian cohort may have affected the results of the study by the International Agency for Research on Cancer on the radiogenic cancer risk among nuclear industry workers in 15 countries. J Radiol Prot 30: 121–129. | Article | PubMed |
  2. Boice JD (2010) Uncertainties in studies of low statistical power. J Radiol Prot 30: 115–120. | Article | PubMed |
  3. Cardis E, Gilbert ES, Carpenter L, Howe G, Kato I, Armstrong BK, Beral V, Cowper G, Douglas A, Fix J, Fry SA, Kaldor J, Lavé C, Salmon L, Smith PG, Voelz GL, Wiggs LD (1995) Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res 142: 117–132. | Article | PubMed | ISI | CAS |
  4. Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, Howe G, Kaldor J, Muirhead CR, Schubauer-Berigan M, Yoshimura T, Bermann F, Cowper G, Fix J, Hacker C, Heinmiller B, Marshall M, Thierry-Chef I, Utterback D, YO Ahn, Amoros E, Ashmore P, Auvinen A, Bae JM, Solano JB, Biau A, Combalot E, Deboodt P, Diez Sacristan A, Eklof M, Engels H, Engholm G, Gulis G, Habib R, Holan K, Hyvonen H, Kerekes A, Kurtinaitis J, Malker H, Martuzzi M, Mastauskas A, Monnet A, Moser M, Pearce MS, Richardson DB, Rodriguez-Artalejo F, Rogel A, Tardy H, Telle-Lamberton M, Turai I, Usel M, Veress K (2005) Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. Br Med J 331: 77. | Article |
  5. Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, Howe G, Kaldor J, Muirhead CR, Schubauer-Berigan M, Yoshimura T, Bermann F, Cowper G, Fix J, Hacker C, Heinmiller B, Marshall M, Thierry-Chef I, Utterback D, Ahn YO, Amoros E, Ashmore P, Auvinen A, Bae JM, Bernar J, Biau A, Combalot E, Deboodt P, Diez Sacristan A, Eklöf M, Engels H, Engholm G, Gulis G, Habib RR, Holan K, Hyvonen H, Kerekes A, Kurtinaitis J, Malker H, Martuzzi M, Mastauskas A, Monnet A, Moser M, Pearce MS, Richardson DB, Rodriguez-Artalejo F, Rogel A, Tardy H, Telle-Lamberton M, Turai I, Usel M, Veress K (2007) The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the nuclear industry: estimates of radiation-related cancer risks. Radiat Res 167: 396–416. | Article | PubMed | ISI | CAS |
  6. Gilbert ES, Fry SA, Wiggs LD, Voelz GL, Cragle DL, Petersen GR (1989) Analyses of combined mortality data on workers at the Hanford Site, Oak Ridge National Laboratory, and Rocky Flats Nuclear Weapons Plant. Radiat Res 120: 19–35. | Article | PubMed |
  7. Gribbin MA, Weeks JL, Howe GR (1993) Cancer mortality (1956-1985) among male employees of Atomic Energy of Canada Limited with respect to occupational exposure to external low-linear-energy-transfer ionizing radiation. Radiat Res 133: 375–380. | Article | PubMed |
  8. Hutchison GB, MacMahon B, Jablon S, Land CE (1979) Review of report by Mancuso, Stewart and Kneale of radiation exposure of Hanford workers. Health Phys 37: 207–220. | Article | PubMed |
  9. Kendall GM, Muirhead CR, MacGibbon BH, O'Hagan JA, Conquest AJ, Goodill AA, Butland BK, Fell TP, Jackson DA, Webb MA, Haylock RGE, Thomas JM, Silk TJ (1992) Mortality and occupational exposure to radiation: first analysis of the National Registry for Radiation Workers. Br Med J 304: 220–225. | Article | CAS |
  10. Mancuso TF, Stewart A, Kneale G (1977) Radiation exposures of Hanford workers dying from cancer and other causes. Health Phys 33: 369–385. | Article | PubMed |
  11. Muirhead CR, O'Hagan JA, Haylock RG, Phillipson MA, Willcock T, Berridge GL, Zhang W (2009) Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. Br J Cancer 100: 206–212. | Article | PubMed |
  12. Royal Commission on Environmental Pollution (Chairman: Sir Brian Flowers) (1976) Sixth Report. Nuclear Power and the Environment. Her Majesty’s Stationery Office: London.
  13. United Nations Scientific Committee on the Effects of Atomic Radiation (2008) Effects of Ionizing Radiation. Volume I: UNSCEAR 2006 Report to the General Assembly, with Scientific Annexes. Annex A: Epidemiological Studies of Radiation and Cancer pp 13–322. United Nations: New York.
  14. Wakeford R (2005) Cancer risk among nuclear workers. J Radiol Prot 25: 225–228. | Article | PubMed |
  15. Wakeford R (2009a) Radiation in the workplace-a review of studies of the risks of occupational exposure to ionising radiation. J Radiol Prot 29: A61–A79. | Article | PubMed |
  16. Wakeford R (2009b) More on the risk of cancer among nuclear workers. J Radiol Prot 29: 1–4. | Article |
  17. Zablotska LB, Ashmore JP, Howe GR (2004) Analysis of mortality among Canadian nuclear power industry workers after chronic low-dose exposure to ionizing radiation. Radiat Res 161: 633–641. | Article | PubMed |
  18. Zablotska LB, Lane RSD, Thompson PA (2013) A reanalysis of cancer mortality in Canadian nuclear workers (1957–1994) based on revised exposure and cohort data Br J Cancer e-pub ahead of print 14 November 2013; doi:10.1038/bjc.2013.592. | Article |

The 2005 study is part of the BEIR VII report (2006) as Appendix E.

From the 2005 report (Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries):

Fig 1 Distribution of cumulative radiation doses among workers included in the analyses

Fig 2 Excess relative risks per Sv for all cancer excluding leukaemia in cohorts with more than 100 deaths (NPP=nuclear power plants, ORNL=Oak Ridge National Laboratory)

The Canadian Nuclear Safety Commission (CNSC) issued a report in June 2011 after they scrutinized the Canadian data.

From the executive summary of the CNSC report (emphasis is mine):

Reanalysis Main Findings

The main findings and recommendations from this reanalysis are:
• Approximately 42,200 NEWs [nuclear energy workers] from Hydro-Québec, New Brunswick Power Corporation, Ontario
Hydro, and Atomic Energy of Canada limited (AECl), first employed since 1965, had no increase in
risk of solid cancer mortality in relation to radiation exposure.
A group of 3,088 AECl NEWs first employed before 1965 (1956-1964) was the only group of workers
with a consistent radiation-associated increase in risk of solid cancer mortality.
The risk estimate was
statistically significant and was nine times higher than the risk estimates for workers with zero dose.
This group of AECl NEWs had a profound impact on the Canadian and 15-country study findings.
It is very likely that these early AECl NEWs have incomplete dose information (i.e., their doses are
Despite this apparent increase in cancer risk among early AECl NEWs, a comparison using the
Canadian Mortality Database showed statistically significant lower rates of all causes of death and
cancer mortality for this group than for the general Canadian population
. This fact reinforces CNSC
concerns that there remains a data problem as opposed to a true increase in their risk of solid cancer
• Further investigation of this group of early AECl NEWs is necessary to ensure the accuracy and
completeness of radiation dose records in the National Dose Registry (NDR).

Conclusions and Path Forward

• The CNSC’s reanalysis confirms that there is no increased cancer risk among any Canadian nuclear
power plant workers for any time period or for AECl NEWs first employed since 1965.
• While the data suggests an increased solid cancer mortality risk for AECl NEWs first employed
before 1965 (1956-1964), a comparison using the Canadian Mortality Database shows lower rates of
all causes of death and cancer mortality for this group than for the general Canadian population.
The CNSC does not have confidence in the historical AECl dose data (1956-1964). The apparent
increase in the risk of solid cancer mortality for these early AECl NEWs deserves further
• The CNSC, Health Canada and AECl are further assessing the dose data of early AECl NEWs to
resolve the existing outstanding issues. Health Canada has agreed not to share the Canadian cohort
for any further epidemiological research until the quality of the data file has been confirmed.

Effort, often systematic, to underestimate radiation exposure of the Fukushima I NPP workers would mean the dose data of the workers cannot be used in epidemiological studies in the future.


Anonymous said...

Fukushima workers' data should still be studied and results be "footnoted" in the sense that exposure may have been underrecorded. If related diseases were therefore to be overreported, it would simply mean we'd err on the side of caution.

Anonymous said...

mscharisma, maybe. But it would not be a scientific study that researchers could quote.

Tam B said...

Thank you for posting this - highly informative.

Anonymous said...

At Anon @ 11:41: Agree, but I would consider it important data nonetheless.

Anonymous said...

I think the volume of data from Fukushima - workers as well as residents who carry the "glass badges" - will be extremely useful for this generation and future generations. Even if there is systematic under-reporting, there will be enough data on radiation levels at the plant to triangulate estimated doses with reported doses, and epidemiologists can calculate the standard deviation from the sample. And even given the under reporting that we know is going on, there will be some whose doses are reasonably accurately reported. I don't think the data is a write-off, by any stretch of the imagination.

Anonymous said...

Well, it still doesn't change the fact that less man-made radioactive contamination is better.

Anonymous said...

Excellent article EX-SKF. Thanks for publishing this data.

Anonymous said...

Great article on how to throw away data you do not like.
However, until there will be a general consensus in the scientific community that radioactive waste is good for your health it better to err on the safe side and avoid to buy those tasty mushrooms from Fukushima.

Zahul Khan said...

Hey, This is a really good post. Must admit that you are amongst the best bloggers I have read. Thanks for posting this informative article.

Embassy In Chennai

Post a Comment